China launched an ambitious mission on Tuesday to bring back rocks and debris from the moon’s surface for the first time in more than 40 years — an undertaking that could boost human understanding of the moon and of the solar system more generally.

Chang’e 5 — named for the Chinese moon goddess — is the country’s boldest lunar mission yet. If successful, it would be a major advance for China’s space program, and some experts say it could pave the way for bringing samples back from Mars or even a crewed lunar mission.

The four modules of the Chang’e 5 spacecraft blasted off at just after 4:30 a.m. Tuesday (2030 GMT Monday, 3:30 p.m. EST Monday) atop a massive Long March-5Y rocket from the Wenchang launch center along the coast of the southern island province of Hainan.

Minutes after liftoff, the spacecraft separated from the rocket’s first and second stages and slipped into Earth-moon transfer orbit. About an hour later, Chang’e 5 opened its solar panels to provide its independent power source.

Spacecraft typically take three days to reach the moon.

The launch was carried live by national broadcaster CCTV which then switched to computer animation to show its progress into outer space.

The mission’s key task is to drill 2 meters (almost 7 feet) beneath the moon’s surface and scoop up about 2 kilograms (4.4 pounds) of rocks and other debris to be brought back to Earth, according to NASA. That would offer the first opportunity for scientists to study newly obtained lunar material since the American and Russian missions of the 1960s and 1970s.

The Chang’e 5 lander’s time on the moon is scheduled to be short and sweet. It can only stay one lunar daytime, or about 14 Earth days, because it lacks the radioisotope heating units to withstand the moon’s freezing nights.

The lander will dig for materials with its drill and robotic arm and transfer them to what’s called an ascender, which will lift off from the moon and dock with the service capsule. The materials will then be moved to the return capsule to be hauled back to Earth.

The technical complexity of Chang’e 5, with its four components, makes it “remarkable in many ways,” said Joan Johnson-Freese, a space expert at the U.S. Naval War College.

“China is showing itself capable of developing and successfully carrying out sustained high-tech programs, important for regional influence and potentially global partnerships,” she said.

In particular, the ability to collect samples from space is growing in value, said Jonathan McDowell, an astronomer at the Harvard-Smithsonian Center for Astrophysics. Other countries planning to retrieve material from asteroids or even Mars may look to China’s experience, he said.

While the mission is “indeed challenging,” McDowell said China has already landed twice on the moon with its Chang’e 3 and Chang’e 4 missions, and showed with a 2014 Chang’e 5 test mission that it can navigate back to Earth, re-enter and land a capsule. All that’s left is to show it can collect samples and take off again from the moon.

“As a result of this, I’m pretty optimistic that China can pull this off,” he said.

The mission is among China’s boldest since it first put a man in space in 2003, becoming only the third nation to do so after the U.S. and Russia.

Chang’e 5 and future lunar missions aim to “provide better technical support for future scientific and exploration activities,” Pei Zhaoyu, mission spokesperson and deputy director of the Chinese National Space Administration’s Lunar Exploration and Space Engineering Center told reporters at a Monday briefing.

“Scientific needs and technical and economic conditions” would determine whether China decides to send a crewed mission to the moon, said Pei, whose comments were embargoed until after the launch. “I think future exploration activities on the moon are most likely to be carried out in a human-machine combination.”

While many of China’s crewed spaceflight achievements, including building an experimental space station and conducting a spacewalk, reproduce those of other countries from years past, the CNSA is now moving into new territory.

Chang’e 4 — which made the first soft landing on the moon’s relatively unexplored far side almost two years ago — is currently collecting full measurements of radiation exposure from the lunar surface, information vital for any country that plans to send astronauts to the moon.

China in July became one of three countries to have launched a mission to Mars, in China’s case an orbiter and a rover that will search for signs of water on the red planet. The CNSA says the spacecraft Tianwen 1 is on course to arrive at Mars around February.

China has increasingly engaged with foreign countries on missions, and the European Space Agency will be providing important ground station information for Chang’e 5.

U.S. law, however, still prevents most collaborations with NASA, excluding China from partnering with the International Space Station. That has prompted China to start work on its own space station and launch its own programs that have put it in a steady competition with Japan and India, among Asian nations seeking to notch new achievements in space.

China’s space program has progressed cautiously, with relatively few setbacks in recent years. The rocket being used for the current launch failed on a previous launch attempt, but has since performed without a glitch, including launching Chang’e 4.

“China works very incrementally, developing building blocks for long-term use for a variety of missions,” Freese-Johnson said. China’s one-party authoritarian system also allows for “prolonged political will that is often difficult in democracies,” she said.

While the U.S. has followed China’s successes closely, it’s unlikely to expand cooperation with China in space amid political suspicions, a sharpening military rivalry and accusations of Chinese theft of technology, experts say.

“A change in U.S. policy regarding space cooperation is unlikely to get much government attention in the near future,” Johnson-Freese said.

Read Also: SpaceX capsule with 4 astronauts reaches space station

Two drugmakers, Pfizer and Moderna, have announced promising interim results for their vaccine candidates, raising hopes that the end of the pandemic may be in sight. But, if and when the vaccines are authorized by the Food and Drug Administration, distributing them presents a daunting challenge, reports NPR.

One of the front-runners in the vaccine race — the one made by Pfizer — needs to be kept extremely cold: minus 70 degrees Celsius, which is colder than winter in Antarctica. Moderna has said that its vaccine needs to be frozen too, but only at minus 20 Celsius, more like a regular freezer.

Since there will be limited vaccine doses at first, immunization managers across the country will need to have plans to distribute any and all vaccine doses that are available. For months, they've been puzzling over the particular challenges presented by the Pfizer vaccine, which requires these ultra-cold conditions.

"I believe it can be done," said Debra Kristensen, a 30-year veteran of vaccine innovation and supply chains at PATH, an international nonprofit focused on public health, to NPR. "Ebola vaccine, for example, was successfully used in a few African countries and also required this ultra-cold chain storage."

Distributing vaccines in these conditions "is possible, but it's definitely going to be much more expensive and more difficult," she says. Pfizer has tried to calm concerns about the challenges presented by these cold temperatures. It has designed its own packaging to keep doses super cold with dry ice, so that they can be stored for a few weeks without specialized freezers (the packaging has been informally nicknamed "the pizza box").

Moderna's vaccine, Kristensen explains, "can be distributed in more of a standard fashion — health workers are used to it, facilities are used to it — it's more normal."

Here's some background on why these vaccines need to be kept so cold — and how they differ.

Both the Moderna and Pfizer vaccine candidates use a new approach to unlock the body's immune defenses. The approach uses messenger RNA, or mRNA, to turn a patient's cells into factories that make one particular coronavirus protein.

That protein kicks off an immune response as if there was a real coronavirus infection (to be clear, since it's only one virus protein, there's no way the vaccine could actually infect someone or make them sick with COVID-19). Then, if someone who was immunized gets exposed to the coronavirus later on, their body's immune system will be able to fight it off more easily and they're more likely to avoid serious illness.

It's a vaccine technology that's so new, no mRNA vaccines have ever been approved by the Food and Drug Administration.

Vaccines made from mRNA can be made much faster than older vaccines could, explains Margaret Liu, a vaccine researcher who chairs the board of the International Society for Vaccines and specializes in genetic vaccines, to NPR. The problem, says Liu, is that mRNA is "really easily destroyed, and that's because there are many, many enzymes that will just break it apart."

Here's an analogy: Think of the vaccine as a chocolate bar that melts easily. Just as there are ways to keep the chocolate from melting into goo, there are things the drugmakers did to protect their COVID-19 vaccines.

The first step, Liu says, was to modify the mRNA nucleosides — the "building blocks" of the RNA vaccine. "They've used modified versions because those are more stable," she says. This would be like changing the chocolate recipe so it's not quite so melty.

The next step was to use lipid nanoparticles, which, Liu explains, "is kind of like putting your chocolate inside a candy coating — you have an M&M, so the chocolate doesn't melt."

But even with the stabilized building blocks and lipid coating, the mRNA could still fall apart easily, which is why the vaccine is frozen.

"Everything happens more slowly as you lower the temperature," Liu says. "So your chemical reactions — the enzymes that break down RNA — are going to happen more slowly." It's the same idea as freezing food to keep it from spoiling.

Because the specific formulations are secret, Liu says, it's not clear exactly why these two mRNA vaccines have different temperature requirements.

"It just comes down to what their data is," she says of Moderna's vaccine. "If their data shows that it's more stable at a certain temperature, that's it."

Moderna spokesperson Colleen Hussey explained to NPR in an email that its vaccine doesn't need to be kept so cold because of its particular "lipid nanoparticle properties and structure," and because the company has learned from experience — it's developed ten mRNA vaccine candidates already. "Now we don't need [ultra-cold conditions] as the quality of product has improved and [it] doesn't need to be highly frozen to avoid mRNA degradation," Hussey explained.

It's possible that Pfizer's vaccine could eventually be shown to be stable in somewhat warmer conditions — or for longer times out of the freezer.

To figure out a vaccine's temperature requirements, drugmakers do extensive, time-consuming thermostability studies.

That research involves keeping the vaccine "at other temperatures to see how much you can stress the system," explains Liu. She says you would start at ultra-cold temperatures, then try regular freezer temperature, then refrigerator temperature, and finally room temperature.

You might also put the vaccine at fluctuating temperatures "to sort of mimic what would happen if [a vaccine shipment] got left on a loading dock and something went wrong," Liu says.

Then drugmakers have to analyze the vaccine samples that have been put through all that and do tests (usually in mice) to see if the vaccine still works the way it's supposed to.

All of this is measured in real time. "If a vaccine has a two-year shelf life at refrigerator temperatures, then the manufacturer actually needs to put the vaccine at that refrigerated temperature for two years and see if at the end the product is still effective," Kristensen explains. "Given the urgent need for these COVID-19 vaccines, manufacturers will likely begin releasing them with shorter shelf lives and then they'll expand the shelf life durations as they gather more data."

Pfizer spokesperson Jerica Pitts told NPR "there are ongoing studies on this front," but did not answer whether any imminent changes to the temperature requirements might be coming as a result of those studies.

"I doubt that [Pfizer] will be able to move away from the ultra-cold conditions during initial transport and storage," says Kristensen. "But if they can prove that the vaccine can be kept at refrigerated temperatures for some time after being removed from frozen storage, that helps facilitate distribution and administration out to more remote areas and to specific groups of people."

Temperature requirements call for different distribution plans

Right now, Pfizer says its vaccine needs to be kept at minus 70 degrees Celsius and can last in a specialty freezer for up to six months. The specialty shippers can hold up to five "pizza box" trays of vials and be refreshed with dry ice every five days for up to 15 days to keep the vaccine at the right frozen temperature.

Also read: With Pfizer’s vaccine mostly reserved by rich countries, eyes still on firms partnering Oxford candidate

Even that presents challenges, though — a Pfizer scientist told a CDC advisory council in August that it's not supposed to be opened more than twice a day and needs to be closed within one minute of opening. Once it's thawed, the vaccine can be refrigerated for five days.

Moderna says its vaccine candidate is stable at regular freezer temperature — minus 20 degrees Celsius — for up to six months, and after thawing it can last in the refrigerator for 30 days. It can also be kept at room temperature for up to 12 hours. This, explains Kristensen, is useful for health care workers in the field, "because now the vaccine doesn't need to go in and out of the refrigerator each time it's administered."

Given the demand, if both Pfizer and Moderna's vaccines are authorized around the same time, states will figure out how to use both in different settings.

Christine Finley, the immunization manager in Vermont finalizing that state's distribution plan, says it makes sense to think about distributing Pfizer's vaccine to larger population centers, not just because of its temperature, but because the smallest amount you can order is 975 doses (usually it's more like 100 doses or fewer).

"[If] you have a large university where you're going to be able to reach a larger number of people, that would make sense that you might consider distributing your ultra-cold there," she says. The Moderna vaccine will work better, she says, "in areas where it might be more difficult to use up such a large order or they may not have the [cold] storage."

Also read: 2nd coronavirus vaccine shows striking success in US tests

The Centers for Disease Control and Prevention, the federal agency in charge of vaccine distribution and decisions about which groups receive the first shots, has tried to discourage health departments and hospitals from going out and buying expensive freezers to accommodate the Pfizer vaccine. But according to a recent report in Stat, wealthier hospitals are buying up specialized freezers, raising concerns that hospitals with fewer resources or in rural areas will be left behind.

Moderna's announcement may temper those fears, although since Pfizer's vaccine doses will be urgently needed as well, it doesn't mean that ultra-cold storage is no longer an issue.

"I think the best news is that there may be two vaccines that are effective because that means we can reach more people," says Finley. "We still need to show that they're safe and they're effective and we need to build trust with the public — so there's still a ways to go, but this is good news."

Despite the excitement and hopes riding on Pfizer and Moderna potentially having the first authorized COVID-19 vaccines, "this really isn't a race," says Liu. "Just by sheer numbers, we probably need multiple, multiple vaccines."

And in the end, she says, "it may be that the second one or the 50th one is actually a better vaccine."

Also read: Who will be the first to get COVID-19 vaccines?

SpaceX’s newly launched capsule with four astronauts arrived Monday at the International Space Station, their new home until spring.

The Dragon capsule pulled up and docked late Monday night, following a 27-hour, completely automated flight from NASA’s Kennedy Space Center. The linkup occurred 262 miles (422 kilometers) above Idaho.

“Oh, what a good voice to hear,” space station astronaut Kate Rubins called out when the Dragon’s commander, Mike Hopkins, first made radio contact.

“We can’t wait to have you on board,” she added after the two spacecraft were latched together.

This is the second astronaut mission for SpaceX. But it’s the first time Elon Musk’s company delivered a crew for a full half-year station stay. The two-pilot test flight earlier this year lasted two months.

The three Americans and one Japanese astronaut will remain at the orbiting lab until their replacements arrive on another Dragon in April. And so it will go, with SpaceX — and eventually Boeing — transporting astronauts to and from the station for NASA.

This regular taxi service got underway with Sunday night’s launch.

Hopkins and his crew — Victor Glover, Shannon Walker and Japan’s Soichi Noguchi — join two Russians and one American who flew to the space station last month from Kazakhstan. Glover is the first African-American to move in for a long haul. A space newcomer, Glover was presented his gold astronaut pin Monday.

The four named their capsule Resilience to provide hope and inspiration during an especially difficult year for the whole world. They broadcast a tour of their capsule Monday, showing off the touchscreen controls, storage areas and their zero gravity indicator: a small plush Baby Yoda.

Walker said it was a little tighter for them than for the two astronauts on the test flight.

“We sort of dance around each other to stay out of each other’s way,” she said.

For Sunday’s launch, NASA kept guests to a minimum because of coronavirus, and even Musk had to stay away after tweeting that he “most likely” had an infection. He was replaced in his official launch duties by SpaceX President Gwynne Shotwell, who assured reporters he was still very much involved with Sunday night’s action, although remotely.

As they prepared for the space station linkup, the Dragon crew beamed down live window views of New Zealand and a brilliant blue, cloud-streaked Pacific 250 miles below.

“Looks amazing,” Mission Control radioed from SpaceX headquarters in Hawthorne, California.

“It looks amazing from up here, too,” Hopkins replied.

Also read: SpaceX crew flight delayed; Musk gets mixed COVID-19 results

China's third-generation space tracking ship Yuanwang-6 departed on Friday for multiple spacecraft monitoring missions.

The ship will carry out missions in the Pacific Ocean and the Indian Ocean and operate at sea for more than 90 days, said Luo Haiting, head of the ship's human resource department, reports Xinhua.

Yuanwang-6 has already performed four maritime monitoring missions since the beginning of 2020, including maritime monitoring for the last satellite launch for China's BeiDou Navigation Satellite System (BDS-3).

The ship had completed an overhaul, equipment precision appraisals and training of crew members before the departure.

Also read: Construction of China's space station about to start

The lander and the rover of the Chang'e-4 probe have been switched to the dormant mode for the lunar night after working stably for the 23rd lunar day, according to the Lunar Exploration and Space Program Center of the China National Space Administration.

A lunar day is equal to 14 days on Earth, and a lunar night is the same length. The Chang'e-4 probe, which switched to dormant mode during the lunar night due to the lack of solar power, had been on the far side of the moon for 660 Earth days as of Saturday, and the rover has traveled 565.9 meters.

The lander was switched to dormant mode at 9:40 p.m. Friday (Beijing Time) as scheduled, and the rover, Yutu-2 (Jade Rabbit-2), at 12 noon Friday, said the center.

During the 23rd lunar day, Yutu-2 went northwest, traveling toward an area with basalt and an impact crater area with high reflectivity. En route to the destination, the near-infrared spectrometer on the rover was used to detect a rock about 30 cm in diameter. The research team is analyzing the transmitted data.

Scientists carried out the first systematically documented measurements of radiation on the moon with data acquired by the neutron radiation detector onboard. According to the study published in the journal Science Advances, the moon's surface is highly radioactive, approximately two to three times the International Space Station, five to ten times a civil flight, and 300 times the surface of the earth of Beijing.

The study provided a reference for the estimation of the lunar surface radiation hazards and the design of radiation protection for future lunar astronauts.

The Chang'e-4 probe, launched on Dec. 8, 2018, made the first-ever soft landing on the Von Karman Crater in the South Pole-Aitken Basin on the far side of the moon on Jan. 3, 2019.

The rover Yutu-2 has far exceeded its three-month design lifespan, becoming the longest-working lunar rover on the moon.

Oct. 24 is a significant day for China's lunar exploration.

On Oct. 24, 2007, China's first lunar probe Chang'e-1 was launched, making China the fifth country to develop and launch a lunar probe on its own and opening up a new age of deep space exploration for China.

It mapped 3D images of the lunar surface, analyzed the distribution of elements, measured the depth of lunar soil, and explored the environment between Earth and moon. Chinese scientists released the first complete map of the moon's surface in November 2008, thanks to Chang'e-1.

After orbiting the moon for about 16 months, the probe made a controlled crash on the lunar surface in March 2009.

On Oct. 24, 2014, China launched an experimental spacecraft to test technologies to be used in the Chang'e-5, which is expected to bring moon samples back to Earth.

The spacecraft, comprising a re-entry capsule and a service module, flew around the moon for half a circle. The return capsule touched down at the designated landing area in Siziwang Banner, north China's Inner Mongolia Autonomous Region, on Nov. 1, 2014.

Read Also: Touch-and-go: US spacecraft sampling asteroid for return