A VVIP flight of Emirates Airlines carrying the President and his entourage departed from Hazrat Shahjalal International Airport at 1:35am, according to Bangabhaban.
Abdul Hamid's wife Rashida Khanom and secretaries are accompanying him during the tour.
The President is scheduled to attend the Presidential Command Transfer Ceremony on March 1 when his Uruguayan counterpart Luis Lacalle Pou will take office.
He will later attend another programme in London to cap the trip.
The President is expected to return home on March 9.