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Whannell helped dust off the classic H.G. Wells story and update it for modern audiences by focusing on Moss' victim character instead of the Invisible Man character, who here is an abusive ex-boyfriend.
"The Invisible Man" carried a relatively modest budget, costing under $10 million to produce, and exceeded expectations by a few million dollars. The film, which had been well-received by critics, drew diverse audiences to the theaters (46% Caucasian, 20% African American and 18% Hispanic), according to exit polls.
"We couldn't be more pleased," said Jim Orr, Universal's president of domestic distribution. "(Whannell) brought this century-old character to life in a very clever and relevant way."
The studio expects it to continue to play well into March, although it will have some extra competition when "A Quiet Place Part II" opens on March 20.
Paramount Pictures' "Sonic the Hedgehog" slid to second place in its third weekend in theaters adding $16 million and bringing its domestic total to $128.3 million. "The Call of the Wild," with Harrison Ford, placed third in its second weekend with $13.2 million.
Fourth place went to the anime superhero film "My Hero Academia: Heroes Rising" which opened to $6.3 million from just 1,260 screens.
"We should never underestimate films like this that may not have broad recognition among the general public," said Comscore's senior media analyst Paul Dergarabedian.
"Bad Boys for Life" rounded out the top five with $4.3 million in its seventh weekend. The Will Smith and Martin Lawrence pic is just shy of reaching the $200 million mark in North America and has earned over $400 million globally.
In limited release, "Wendy," Benh Zeitlin's long-awaited follow-up to his Oscar-nominated film "Beasts of the Southern Wild," got off to a bumpy start with just $30,000 from four theaters. The Peter Pan-inspired film has garnered mixed reviews from critics and will be expanding in the coming weeks.
Although it's still early in the year, overall the box office is up nearly 3.5%.
"This weekend it was business as usual in North American theaters," Dergarabedian said. "People went to the movies to escape the trials and tribulations of the real world."
Estimated ticket sales for Friday through Sunday at U.S. and Canadian theaters, according to Comscore. Where available, the latest international numbers for Friday through Sunday are also included. Final domestic figures will be released Monday.
1. "The Invisible Man," $29 million ($20.2 million international).
2. "Sonic The Hedgehog," $16 million ($26.8 million international).
3. "The Call of the Wild," $13.2 million ($11 million international).
4. "My Hero Academia: Heroes Rising," $6.3 million ($117,000 international).
5. "Bad Boys for Life," $4.3 million ($4.9 million international).
6. "Birds of Prey," $4.1 million ($4.6 million international).
7. "Impractical Jokers: The Movie," $3.5 million.
8. "1917," $2.7 million ($5.3 million international).
9. "Brahms: The Boy II," $2.6 million ($2.4 million international).
10. "Blumhouse's Fantasy Island," $2.3 million ($1.9 million international).
Estimated ticket sales for Friday through Sunday at international theaters (excluding the U.S. and Canada), according to Comscore:
1. "Sonic The Hedgehog," $26.8 million.
2. "The Invisible Man," $20.2 million.
3. "The Call of the Wild," $11 million.
4. "The Gentlemen," $8.5 million.
5. "Dolittle," $6.4 million.
6. "Parasite," $5.8 million.
7. "1917," $5.3 million.
8. "Bad Boys for Life," $4.9 million.
9. "Birds of Prey," $4.6 million.
10. "10 Jours Sans Maman," $2.7 million.