Pope Francis on Monday named the first woman to head a major Vatican office, appointing an Italian nun, Sister Simona Brambilla, to become prefect of the department responsible for all the Catholic Church's religious orders.

The appointment marks a major step in Francis’ aim to give women more leadership roles in governing the church. While women have been named to No. 2 spots in some Vatican offices, never before has a woman been named prefect of a dicastery or congregation of the Holy See Curia, the central governing organ of the Catholic Church.

The historic nature of Brambilla’s appointment was confirmed by Vatican Media, which headlined its report “Sister Simona Brambilla is the first woman prefect in the Vatican.”

The office is one of the most important in the Vatican. Known officially as the Dicastery for the Institutes of Consecrated Life and Societies of Apostolic Life, it is responsible for every religious order, from the Jesuits and Franciscans to smaller newer movements.

In an indication of the novelty of the appointment, and the theological implications involved, Francis simultaneously named as a co-leader, or “pro-prefect,” a cardinal: Ángel Fernández Artime, a Salesian.

But the appointment, announced in the Vatican daily bulletin, lists Brambilla first as “prefect” and Fernández second as her co-leader, which theologically is necessary since the prefect must be able to celebrate Mass and perform other sacramental functions that currently can only be done by men.

Brambilla, 59, is a member of the Consolata Missionaries religious order and had served as the No. 2 in the religious orders department since last year. She takes over from the retiring Cardinal Joao Braz de Aviz, 77.

Francis made Brambilla’s appointment possible with his 2022 reform of the Holy See’s founding constitution, which allowed laypeople, including women, to head a dicastery and become prefects.

Brambilla, a nurse, worked as a missionary in Mozambique and led her Consolata order as superior from 2011-2023, when Francis made her secretary of the religious orders department.

Her appointment is the latest move by Francis to show by example how women can take leadership roles within the Catholic hierarchy, albeit without allowing them to be ordained as priests.

Catholic women do much of the church’s work in schools, hospitals and passing down the faith to future generations. But they have long complained of second-class status in an institution that reserves the priesthood for men.

Francis has upheld the ban on female priests and tamped down hopes that women could be ordained as deacons.

But there has been a marked increase in the percentage of women working in the Vatican during his papacy, including in leadership positions, from 19.3% in 2013 to 23.4% today, according to statistics reported by Vatican News. In the Curia alone, the percentage of women is 26%.

Among the women holding leadership positions are Sister Raffaella Petrini, the first-ever female secretary general of the Vatican City State, responsible for the territory’s health care system, police force and main source of revenue, the Vatican Museums, which are led by a laywoman, Barbara Jatta.

Another nun, Sister Alessandra Smerilli, is the No. 2 in the Vatican development office while several women have been appointed to under-secretary positions, including the French nun, Sister Nathalie Becquart, in the synod of bishops' office.