The Israeli government said a drone targeted the prime minister’s house Saturday, though there were no casualties, as Iran’s supreme leader vowed Hamas would continue its fight following the killing of the mastermind of last year’s deadly Oct. 7 attack.

Sirens wailed in Israel warning of incoming fire from Lebanon. The military said dozens of projectiles were launched. Israeli Prime Minister Benjamin Netanyahu’s office said the drone targeted his house in the Mediterranean coastal town of Caesarea, though neither he nor his wife were home.

The barrage comes as Israel considers its expected response to an Iranian attack earlier this month and presses its offensives against Hamas militants in Gaza and Hezbollah in Lebanon.

In Gaza, Israeli forces fired at hospitals in the battered northern part of the Palestinian enclave, and strikes in the strip killed more than 50 people, including children, in less than 24 hours, according to hospital officials and an Associated Press reporter there.

In September, Yemen’s Houthi rebels launched a ballistic missile toward Ben Gurion Airport when Netanyahu’s plane was landing. The missile was intercepted.

Barrages from Lebanon target northern Israel

In addition to the drone launched at Netanyahu’s private residence, Israel’s military said some 180 projectiles were fired throughout the day from Lebanon on Saturday morning. A 50-year-old man was killed after being hit by shrapnel while sitting in his car in northern Israel, and four people were injured, Israel’s medical services said.

In the northern city of Kiryat Ata, sirens blared as people ran for cover and intercepted missiles exploded in the sky. One rocket landed in the area, and Associated Press reporters saw burned cars and a damaged building. Itzik Billet, commander for the Haifa area, said nine people were lightly injured.

The Israeli fire service also said it was battling several blazes resulting from missiles in the Shlomi area, less than a mile (1 kilometer) from the Lebanese border.

Israel's war with Lebanon’s Hezbollah — a Hamas ally backed by Iran — has intensified in recent weeks. Hezbollah said Friday that it planned to launch a new phase of fighting by sending more guided missiles and exploding drones into Israel. The militant group’s longtime leader, Hassan Nasrallah, was killed in an Israeli airstrike in late September, and Israel sent ground troops into Lebanon earlier in October.

On Saturday, Israel's military issued fresh evacuation warnings for two buildings in Beirut’s southern suburb of Haret Hriek. Israel has issued near-daily warnings for people to leave buildings and villages across parts of Lebanon. The fighting has displaced more than 1 million people, including some 400,000 children.

Israel also said Saturday it killed Hezbollah’s deputy commander in the southern town of Bint Jbeil. The army said Nasser Rashid supervised attacks against Israel.

In Lebanon, the health ministry said an Israeli airstrike Saturday hit a vehicle on a main highway north of Beirut, killing two people. It was unclear who was in the car when it was struck.

Israeli strikes pound Gaza as Hamas rejects hostage release

A standoff is also ensuing between Israel and Hamas, which it’s fighting in Gaza, with both signaling resistance to ending the war after the death of Hamas’ leader Yahya Sinwar this week.

On Friday, Iran’s supreme leader, Ayatollah Ali Khamenei, said Sinwar’s death was a painful loss but noted that Hamas carried on despite the killings of other Palestinian militant leaders before him.

“Hamas is alive and will stay alive,” Khamenei said in his first comments on the killing.

Since Israel claimed Sinwar’s death Thursday, confirmed by a top Hamas official Friday, Hamas has reiterated its stance that the hostages taken from Israel a year ago will not be released until there is a cease-fire in Gaza and a withdrawal of Israeli troops. The staunch position pushed back against a statement by Netanyahu that his country’s military will keep fighting until the hostages are released, and will remain in Gaza to prevent a severely weakened Hamas from rearming.

Sinwar was the chief architect of the 2023 Hamas raid on Israel that killed some 1,200 people, mostly civilians, and kidnapped another 250. Israel’s retaliatory offensive in Gaza has killed over 42,000 Palestinians, according to local health authorities, who do not distinguish combatants from civilians but say more than half the dead are women and children.

More strikes pounded Gaza on Saturday. The Palestinian Health Ministry said in a statement that Israeli strikes hit the upper floors of the Indonesian Hospital in Beit Lahiya, and that forces opened fire at the hospital’s building and its courtyard, causing panic among patients and medical staff.

At Al-Awda hospital in Jabaliya, in northern Gaza, strikes hit the building’s top floors, injuring several staff members, the hospital said in a statement. Three houses in Jabaliya were struck overnight Friday, killing at least 30 people, more than half of them women and children, said Fares Abu Hamza, head of the health ministry’s ambulance and emergency service. At least 80 people were injured.

In central Gaza, at least 10 people were killed, including two children, when a house was hit in the town of Zawayda, according to the al-Aqsa Martyrs Hospital in Deir al-Balah, where the casualties were taken. Another strike killed 11 people, all from the same family, in the Maghazi refugee camp, the same hospital said. Associated Press journalists counted the bodies from both strikes at the hospital.

A United Nations school sheltering displaced people in the west of Gaza City, was also hit, killing several people, according to the Hamas-run civil defense first responders.

The strikes knocked out internet networks in northern Gaza, said Paltel, the Palestinian communications company, on Facebook Saturday.

The war has destroyed vast swaths of Gaza, displaced about 90% of its population of 2.3 million people, and left them struggling to find food, water, medicine and fuel.

Opportunity in Sinwar's death

Sinwar’s killing appeared to be a chance front-line encounter with Israeli troops on Wednesday, and it could shift the dynamics of the war in Gaza even as Israel presses its offensive against Hezbollah with ground troops in southern Lebanon and airstrikes in other areas of the country.

Israel has pledged to destroy Hamas politically in Gaza, and killing Sinwar was a top military priority. But Netanyahu said in a speech Thursday announcing the killing that “our war is not yet ended.”

Still, the governments of Israel’s allies and exhausted residents of Gaza expressed hope that Sinwar’s death would pave the way for an end to the fighting.

In Israel, families of hostages still held in Gaza demanded the Israeli government use Sinwar’s killing as a way to restart negotiations to bring home their loved ones. There are about 100 hostages remaining in Gaza, at least 30 of whom Israel says are dead.