Bangladesh's second innings came to an end at 390 on the third afternoon in Sylhet, setting Pakistan a massive and highly improbable target of 437 runs to win the second Test.
The innings break was triggered when veteran Mushfiqur Rahim was finally dismissed for a magnificent 137 off 233 balls.
Attempting to clear the boundary off Sajid Khan, Mushfiqur was caught at deep midwicket by Mohammad Abbas. His masterclass included 12 boundaries and a six, anchoring the lower order across the day to ensure Bangladesh drove their lead completely out of Pakistan's reach.
Off-spinner Sajid Khan wrapped up the tail to finish with figures of 3-126 from a marathon 33.2 overs, while paceman Khurram Shahzad was the pick of the Pakistani attack with 4-86.
Facing a heavily wearing Day 3 pitch that is already offering sharp turn, Pakistan brace for an uphill battle to save the Test match and prevent a 2-0 series sweep.